Physical Activity Increases Oxidative Stress Biomarker and Enhance the Academic Performance in Primary School Children

Authors

DOI:

https://doi.org/10.5281/zenodo.15109968

Keywords:

Physical activity, oxidative stress, academic performance, children

Abstract

This study aimed to develop a conceptual model to examine the relationship between physical activity (PA), oxidative stress biomarkers, and academic performance. A total of 200 primary school children (100 boys and 100 girls), aged 10–11 years, were randomly assigned to four groups: boys with exercise (boy+Ex), boys without exercise (boy+nonEx), girls with exercise (girl+Ex), and girls without exercise (girl+nonEx). Participants underwent a 12-week treadmill-based running program. Oxidative stress was evaluated through lipid peroxidation by measuring malondialdehyde (MDA) levels. Academic stress was assessed using the Perceived Stress Scale, while academic performance was measured in relation to attention and stress levels. There were significant differences in the concentrations of MDA (mmol/ L) between boy+Ex compared to boy+non Ex, however, the mean MDA in boy +Ex were significantly higher than that in girl +Ex (P<0.01). There was a significant increasing in TC >200mg/dl in boy+Ex compared to boy+non Ex. The mean concentrations of TC significantly differed between the boy+Ex compared to girl+Ex. No significant differences were found in the concentrations of LDL >100mg/dl, HDL and TG >150mg/dl <40mg/dl among groups. No statistical differences were showed in academic stress levels between boys and girls. Although, the performance was significantly higher in the girl+Ex group compared to the boy+Ex group. Academic stress levels did not differ significantly by gender, whereas academic performance was significantly higher in the girl+Ex group. The findings suggest that oxidative stress is not directly associated with academic achievement, while physical activity demonstrates an independent relationship with academic performance in primary school children.

References

Abdullah, B., Jaafar, W. M. W., & Ayub, A. F. M. (2012). The development of gross motor analysis system software: A preliminary concept. Procedia - Social and Behavioral Sciences, 64, 501–506.

Alghadir, A. H., Gabr, S. A., & Al-Eisa, E. S. (2016). Effects of moderate aerobic exercise on cognitive abilities and redox state biomarkers in older adults. Oxidative Medicine and Cellular Longevity, 2016(1), Article 2545168. https://doi.org/10.1155/2016/2545168

Alghadir, A. H., Gabr, S. A., Anwer, S., & Al-Eisa, E. (2016). Fatigue and oxidative stress response to physical activity in type 2 diabetic patients. International Journal of Diabetes in Developing Countries, 36(1), 59–64.

Aouadi, R., Alanazi, H. M. N., & Tim, G. (2015). Impact of physical exercise on reactive time and cognitive function in mentally deficient adolescents. Journal of Clinical Trials, 5(1), 206.

Avloniti, A., Chatzinikolaou, A., Deli, C. K., Vlachopoulos, D., Gracia-Marco, L., Leontsini, D., ... & Fatouros, I. G. (2017). Exercise-induced oxidative stress responses in the pediatric population. Antioxidants, 6(1), 6. https://doi.org/10.3390/antiox6010006

Best, J. R. (2010). Effects of physical activity on children's executive function: Contributions of experimental research on aerobic exercise. Developmental Review, 30(4), 331–551. https://doi.org/10.1016/j.dr.2010.08.001

Booth, F. W., Roberts, C. K., Thyfault, J. P., Ruegsegger, G. N., & Toedebusch, R. G. (2017). Role of Inactivity in Chronic Diseases: Evolutionary Insight and Pathophysiological Mechanisms. Physiological Reviews, 97(4), 1351–1402. https://doi.org/10.1152/physrev.00019.2016

Bussey, K., & Bandura, A. (1999). Social cognitive theory of gender development and differentiation. Psychological Review, 106(4), 676–713. https://doi.org/10.1037/0033-295X.106.4.676

Caputo, V., Pacilli, M. G., Arisi, I., Mazza, T., Brandi, R., Traversa, A., ... & Macrì, S. (2020). Genomic and physiological resilience in extreme environments are associated with a secure attachment style. Translational Psychiatry, 10(1), 185. https://doi.org/10.1038/s41398-020-00869-4

Carmeli, E., Imam, B., Bachar, A., & Merrick, J. (2012). Inflammation and oxidative stress as biomarkers of premature aging in persons with intellectual disability. Research in Developmental Disabilities, 33(2), 369–375.

Chaddock, L., Erickson, K. I., Prakash, R. S., Kim, J. S., Voss, M. W., VanPatter, M., ... & Kramer, A. F. (2010). A neuroimaging investigation of the association between aerobic fitness, hippocampal volume, and memory performance in preadolescent children. Brain Research, 1358, 172–183.

Chaput, J. P., Willumsen, J., Bull, F., Chou, R., Ekelund, U., Firth, J., ... & Katzmarzyk, P. T. (2020). 2020 WHO guidelines on physical activity and sedentary behaviour for children and adolescents aged 5–17 years: Summary of the evidence. International Journal of Behavioral Nutrition and Physical Activity, 17(1), 141. https://doi.org/10.1186/s12966-020-01037-z

Cooper, S. B., Dring, K. J., Morris, J. G., Sunderland, C., Bandelow, S., & Nevill, M. E. (2018). High intensity intermittent games-based activity and adolescents’ cognition: Moderating effect of physical fitness. BMC Public Health, 18(1), 603. https://doi.org/10.1186/s12889-018-5514-6

de Greeff, J. W., Hartman, E., Mullender-Wijnsma, M. J., Bosker, R. J., Doolaard, S., & Visscher, C. (2014). Physical fitness and academic performance in primary school children with and without a social disadvantage. Health Education Research, 29(5), 853–860.

Dubuc, M. M., Aubertin-Leheudre, M., & Karelis, A. D. (2020). Relationship between interference control and working memory with academic performance in high school students: The Adolescent Student Academic Performance longitudinal study (ASAP). Journal of Adolescence, 80, 204–213. https://doi.org/10.1016/j.adolescence.2020.03.001

Erickson, K. I., Hillman, C. H., Stillman, C. M., Ballard, R. M., Bloodgood, B., Conroy, D. E., Macko, R. F., Marquez, D. X., Petruzzello, S. J., & Powell, K. E. (2019). Physical activity, cognition, and brain outcomes: A review of the 2018 physical activity guidelines. Medicine & Science in Sports & Exercise, 51(6), 1242–1251. https://doi.org/10.1249/MSS.0000000000001936

Fisher, G. G., Chaffee, D. S., Tetrick, L. E., Davalos, D. B., & Potter, G. G. (2017). Cognitive functioning, aging, and work: A review and recommendations for research and practice. Journal of Occupational Health Psychology, 22(3), 314–336. https://doi.org/10.1037/ocp0000086

Hafedh, M., & Parnow, A. (2022). Exercise training improves memory and produces changes in the adrenal gland morphology in the experimental autoimmune encephalomyelitis. Endocrine Regulations, 56(1), 31–37.

Hanushek, E. A. (2012). The economic value of education and cognitive skills. In S. L. Desimone & M. M. Kline (Eds.), Handbook of Education Policy Research (pp. 39–56). Routledge.

Hillman, C. H., Buck, S. M., Themanson, J. R., Pontifex, M. B., & Castelli, D. M. (2009). Aerobic fitness and cognitive development: Event-related brain potential and task performance indices of executive control in preadolescent children. Developmental Psychology, 45(1), 114–129. https://doi.org/10.1037/a0014437

James, J., Pringle, A., Mourton, S., & Roscoe, C. M. P. (2023). The effects of physical activity on academic performance in school-aged children: A systematic review. Children, 10(6), 1019. https://doi.org/10.3390/children10061019

Khan, N. A., & Hillman, C. H. (2014). The relation of childhood physical activity and aerobic fitness to brain function and cognition: A review. Pediatric Exercise Science, 26(2), 138–146. https://doi.org/10.1123/pes.2013-0125

Llorente-Cantarero, F. J., Aguilar-Gómez, F. J., Leis, R., Bueno, G., Rupérez, A. I., Anguita-Ruiz, A., ... & Gil-Campos, M. (2021). Relationship between physical activity, oxidative stress, and total plasma antioxidant capacity in Spanish children from the GENOBOX study. Antioxidants, 10(2), 320. https://doi.org/10.3390/antiox10020320

Peake, J. M., Markworth, J. F., Nosaka, K., Raastad, T., Wadley, G. D., & Coffey, V. G. (2015). Modulating exercise-induced hormesis: Does less equal more? Journal of Applied Physiology, 119(3), 172–189. https://doi.org/10.1152/japplphysiol.01055.2014

Phan, D. V., Chan, C. L., Pan, R. H., Yang, N. P., Hsu, H. C., Ting, H. W., & Lai, K. R. (2018). A study of the effects of daily physical activity on memory and attention capacities in college students. Journal of Healthcare Engineering, 2018, 2942930. https://doi.org/10.1155/2018/2942930

Reitznerová, A., Šuleková, M., Nagy, J., Marcinčák, S., Semjon, B., Čertík, M., & Klempová, T. (2017). Lipid peroxidation process in meat and meat products: A comparison study of malondialdehyde determination between modified 2-thiobarbituric acid spectrophotometric method and reverse-phase high-performance liquid chromatography. Molecules, 22(11), 1988. https://doi.org/10.3390/molecules22111988

Shephard, R. J. (1997). Curricular physical activity and academic performance. Pediatric Exercise Science, 9(2), 113–126.

Sohail, N. (2013). Stress and academic performance among medical students. Journal of the College of Physicians and Surgeons Pakistan, 23(1), 67–71.

Stults-Kolehmainen, M. A., & Sinha, R. (2014). The effects of stress on physical activity and exercise. Sports Medicine, 44(1), 81–121. https://doi.org/10.1007/s40279-013-0090-5

Sutkowy, P., Woźniak, A., Mila-Kierzenkowska, C., Szewczyk-Golec, K., Wesołowski, R., Pawłowska, M., & Nuszkiewicz, J. (2021). Physical activity vs. redox balance in the brain: Brain health, aging and diseases. Antioxidants, 11(1), 95. https://doi.org/10.3390/antiox11010095

Tapia, G., Cancino, J., Castro, M., Núñez, Ó., Pavez, R., Villagrán, C., ... & Zbinden, H. (2022). Regular exercise reduces stress and improves attention levels and academic performance of university students during final exams. SSRN. https://doi.org/10.2139/ssrn.4075700

Trudeau, F., & Shephard, R. J. (2008). Physical education, school physical activity, school sports and academic performance. International Journal of Behavioral Nutrition and Physical Activity, 5(1), 10. https://doi.org/10.1186/1479-5868-5-10

van der Niet, A. G., Hartman, E., Smith, J., & Visscher, C. (2014). Modeling relationships between physical fitness, executive functioning, and academic achievement in primary school children. Psychology of Sport and Exercise, 15(4), 319–325. https://doi.org/10.1016/j.psychsport.2014.02.010

Whiteman, A. S., Young, D. E., He, X., Chen, T. C., Wagenaar, R. C., Stern, C. E., & Schon, K. (2014). Interaction between serum BDNF and aerobic fitness predicts recognition memory in healthy young adults. Behavioural Brain Research, 259, 302–312. https://doi.org/10.1016/j.bbr.2013.11.023

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Published

28.03.2025

How to Cite

Hafedh, M. (2025). Physical Activity Increases Oxidative Stress Biomarker and Enhance the Academic Performance in Primary School Children . InnovatioSports Journal, 3(1), 55–64. https://doi.org/10.5281/zenodo.15109968